TCF7L2

Across TCGA cell cohorts, TCF7L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,444 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TCF7L2-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Retrograde transport, endosome to Golgi, and Negative regulation of chromosome organization. Each is linked with TCF7L2 in more than 12 cancer types. Because this analysis shows association rather than direction, both TCF7L2-to-partner and partner-to-TCF7L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by TCF7L2-low versus TCF7L2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7L2→partner) and Y-score (partner→TCF7L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Viral translational termination-reinitiation →	+0.091	+0.922	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Retrograde transport, endosome to Golgi →	+0.066	+0.844	<.001	<.001	3	12
OVARY	Negative regulation of chromosome organization →	+0.078	+0.957	<.001	<.001	3	10
KIDNEY	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.077	+1.198	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of DNA metabolic process →	+0.052	+0.964	<.001	.004	3	10
LARGE_INTESTINE	Copper ion export →	-0.127	-0.762	.006	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,444 associations by consensus.

Viral translational termination-reinitiation by TCF7L2 expression — LARGE_INTESTINE

Explore this box plot interactively →