TCF7L2

Across TCGA cell cohorts, TCF7L2 mutation is significantly associated with the RNA expression of many other genes, with 814 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCF7L2-associated genes across cancer lineages are HHLA1, EN1, and TSSK1B. Each is linked with TCF7L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF7L2-to-partner and partner-to-TCF7L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by TCF7L2-low versus TCF7L2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7L2→partner) and Y-score (partner→TCF7L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	EN1 →	+0.385	+4.350	<.001	.005	3	1
BLOOD_Leukemia	TSSK1B →	+0.015	+3.874	<.001	.005	3	1
BLOOD_Leukemia	OC90 →	+0.009	+4.786	<.001	<.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.471	+3.036	.001	<.001	3	1
LARGE_INTESTINE	CBY1 →	+0.575	+3.619	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 814 associations by consensus.

HHLA1 by TCF7L2 expression — BLOOD_Leukemia

Explore this box plot interactively →