TCF7L1

Across TCGA patient cohorts, TCF7L1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,107 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TCF7L1-associated genes across cancer lineages are TET1, GALNT3, and FADS2. Each is linked with TCF7L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF7L1-to-partner and partner-to-TCF7L1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TCF7L1 versus TET1 in BRCA, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7L1→partner) and Y-score (partner→TCF7L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TET1 →	+0.684	+0.631	.002	<.001	3	2
UCEC	GALNT3 →	-0.768	-0.598	.005	.001	3	1
UCEC	FADS2 →	+1.318	+0.401	<.001	.005	3	1
UCEC	ATP10D →	-0.807	-0.613	.001	.001	3	1
UCEC	ERAP1 →	-0.811	-0.649	.001	.003	3	1
UCEC	SIX2 →	+1.074	+0.500	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,107 associations by consensus.

TCF7L1 vs TET1 — BRCA

Explore this scatter interactively →