TCF7L1

Across TCGA patient cohorts, TCF7L1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF7L1-associated genes across cancer lineages are S6_pS240_S244, C-Raf, and JNK_pT183_Y185. Each is linked with TCF7L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF7L1-to-partner and partner-to-TCF7L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by TCF7L1-low versus TCF7L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7L1→partner) and Y-score (partner→TCF7L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.520	+3.321	.006	.010	3	2
UCEC	C-Raf →	+0.139	+3.169	.037	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.170	-3.169	.030	.019	3	1
UCEC	STAT3_pY705 →	-0.402	-3.700	<.001	.001	3	1
UCEC	Bak →	+0.253	+2.584	.030	.011	3	1
UCEC	14-3-3_beta →	-0.108	-2.979	.021	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

S6_pS240_S244 by TCF7L1 expression — UCEC

Explore this box plot interactively →