TCF7L1

Across TCGA cell cohorts, TCF7L1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TCF7L1-associated genes across cancer lineages are ASB17, OR1L3, and C12orf40. Each is linked with TCF7L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF7L1-to-partner and partner-to-TCF7L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by TCF7L1-low versus TCF7L1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7L1→partner) and Y-score (partner→TCF7L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	OR1L3 →	+0.036	+4.029	<.001	.009	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
OVARY	ARMH2 →	+0.039	+4.228	<.001	.006	3	1
LARGE_INTESTINE	CNTN3 →	+0.616	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ASB17 by TCF7L1 expression — OVARY

Explore this box plot interactively →