TCF7

Across TCGA patient cohorts, TCF7 mutation is significantly associated with the RNA expression of many other genes, with 2,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF7-associated genes across cancer lineages are PRAMEF32P, HSPD1P3, and TCERG1L-AS1. Each is linked with TCF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF7-to-partner and partner-to-TCF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF32P grouped by TCF7-low versus TCF7-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7→partner) and Y-score (partner→TCF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRAMEF32P →	+0.029	+7.954	<.001	.008	3	2
SKCM	HSPD1P3 →	+0.114	+4.044	<.001	.003	3	2
UCEC	TCERG1L-AS1 →	+0.195	+1.496	<.001	.007	3	2
UCEC	SYPL1P1 →	+0.076	+2.216	<.001	.001	3	2
LIHC	NUDT19P4 →	+0.050	+4.894	<.001	.004	3	1
LIHC	CSN3 →	+0.688	+3.809	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,148 associations by consensus.

PRAMEF32P by TCF7 expression — HNSC

Explore this box plot interactively →