TCF7

Across TCGA cell cohorts, TCF7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,827 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TCF7-associated GO terms across cancer lineages are Gamma-delta T cell differentiation, Positive regulation of T cell differentiation, and Negative regulation of bone mineralization involved in bone maturation. Each is linked with TCF7 in more than 9 cancer types. Because this analysis shows association rather than direction, both TCF7-to-partner and partner-to-TCF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gamma-delta T cell differentiation grouped by TCF7-low versus TCF7-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7→partner) and Y-score (partner→TCF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Gamma-delta T cell differentiation →	+1.459	+4.192	<.001	<.001	3	10
OVARY	Positive regulation of T cell differentiation →	+0.087	+1.592	<.001	<.001	3	8
BONE	Negative regulation of bone mineralization involved in bone maturation →	+1.264	+2.507	<.001	<.001	3	7
BLOOD_Leukemia	Positive regulation of natural killer cell differentiation →	+0.242	+3.493	.001	<.001	3	7
PANCREAS	Keratinocyte development →	+0.330	+1.486	<.001	<.001	3	7
BLOOD_Leukemia	Gamma-delta T cell activation →	+0.645	+5.485	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,827 associations by consensus.

Gamma-delta T cell differentiation by TCF7 expression — BLOOD_Leukemia

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