TCF7

Across TCGA cell cohorts, TCF7 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCF7-associated genes across cancer lineages are G6PC, OCM2, and FABP9. Each is linked with TCF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF7-to-partner and partner-to-TCF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PC grouped by TCF7-low versus TCF7-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF7→partner) and Y-score (partner→TCF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	G6PC →	+0.047	+4.212	.002	.007	3	1
LUNG_NSCLC_LUAD	OCM2 →	+0.036	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	FABP9 →	+0.031	+4.662	<.001	.005	3	1
BLOOD_Leukemia	OR10T2 →	+0.584	+4.276	.005	.007	3	1
BLOOD_Leukemia	DPRX →	+0.109	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

G6PC by TCF7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →