Across TCGA patient cohorts, TCF4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,962 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TCF4-associated genes across cancer lineages are ZEB1, AKT3, and RGS4. Each is linked with TCF4 in more than 6 cancer types. Because this analysis shows association rather than direction, both TCF4-to-partner and partner-to-TCF4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF4→partner) and Y-score (partner→TCF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZEB1 →	+0.927	+0.528	<.001	<.001	3	7
HNSC	AKT3 →	+0.854	+0.501	<.001	.004	3	6
HNSC	RGS4 →	+0.913	+0.310	.002	.009	3	6
BRCA	CNRIP1 →	+0.830	+0.492	<.001	<.001	3	6
UCEC	TSHZ3 →	+1.169	+0.512	<.001	<.001	3	6
BRCA	JAM3 →	+0.888	+0.523	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,962 associations by consensus.

Exploration

TCF4 survival (RNA) · tumor vs normal (RNA) · all TCF4 data types