Across TCGA patient cohorts, TCF4 mutation is significantly associated with the RNA expression of many other genes, with 3,074 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF4-associated genes across cancer lineages are CDK4P1, NEDD8-MDP1, and SNF8. Each is linked with TCF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TCF4-to-partner and partner-to-TCF4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF4→partner) and Y-score (partner→TCF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	CDK4P1 →	+0.119	+4.421	<.001	.009	3	3
UCEC	NEDD8-MDP1 →	+0.130	+1.464	<.001	<.001	3	3
UCEC	SNF8 →	+0.280	+1.410	<.001	<.001	3	3
UCEC	CDT1 →	+0.640	+1.968	<.001	<.001	3	3
UCEC	THOP1 →	+0.425	+1.525	<.001	<.001	3	3
UCEC	RAD51 →	+0.532	+1.389	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,074 associations by consensus.

Exploration

TCF4 survival (RNA) · tumor vs normal (RNA) · all TCF4 data types