Across TCGA patient cohorts, TCF4 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF4-associated genes across cancer lineages are 4E-BP1_pT70, INPP4B, and PDCD4. Each is linked with TCF4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TCF4-to-partner and partner-to-TCF4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF4→partner) and Y-score (partner→TCF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT70 →	+0.062	+0.951	.048	.037	3	4
UCEC	INPP4B →	-0.235	-2.070	.007	.001	3	3
UCEC	PDCD4 →	-0.406	-1.191	.001	.025	3	3
UCEC	eEF2 →	+0.276	+2.584	.004	<.001	3	2
SKCM	GATA6 →	-0.184	-3.169	.043	.017	3	2
UCEC	HER2_pY1248 →	-0.171	-3.074	.018	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

TCF4 survival (RNA) · tumor vs normal (RNA) · all TCF4 data types