Across TCGA cell cohorts, TCF4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TCF4-associated genes across cancer lineages are IFNW1, RSPH6A, and PTH. Each is linked with TCF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF4-to-partner and partner-to-TCF4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF4→partner) and Y-score (partner→TCF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNW1 →	+0.012	+4.930	.003	.008	3	1
LARGE_INTESTINE	RSPH6A →	+0.154	+3.466	<.001	.005	3	1
BLOOD_Lymphoma	PTH →	+0.023	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	OR52K2 →	+0.012	+5.209	<.001	.005	3	1
SKIN	SPANXN1 →	+0.213	+3.115	.005	.004	3	1
SKIN	CLEC6A →	+0.075	+3.518	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TCF4 survival (RNA) · tumor vs normal (RNA) · all TCF4 data types