TCF4-AS1

Across TCGA pan-cancer cohorts, TCF4-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TCF4-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TCF4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TCF4-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LUSC show a favorable association.

LGG, KIRC, and CHOL are the cancer types where TCF4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Quartile	All	0.393	0.671	.001	31	view →
KIRC	DFS	Tertile	IV	0.307	0.628	.034	18	view →
CHOL	DFS	Tertile	All	0.037	0.486	.001	18	view →
THCA	OS	Tertile	IV	0.720	1.000	.004	18	view →
TGCT	OS	Tertile	All	0.756	0.992	<.001	18	view →
LUAD	OS	Tertile	All	0.846	0.641	.022	15	view →
LUSC	DFS	Quartile	All	0.782	0.661	.007	13	view →
THYM	OS	Tertile	II,III,IV	0.359	0.878	.028	12	view →
BRCA	DFS	Quartile	IV	0.657	0.209	.017	12	view →
PAAD	DFS	Tertile	All	0.312	0.490	.038	9	view →
ESCA	DFS	Median	All	0.918	0.517	.021	9	view →
HNSC	OS	Quartile	IV	0.590	0.383	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

TCF4-AS1–LGG (OS)

Open the LGG breakdown →