TCF3

Across TCGA patient cohorts, TCF3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF3-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and Lck. Each is linked with TCF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF3-to-partner and partner-to-TCF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TCF3-low versus TCF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF3→partner) and Y-score (partner→TCF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.228	+3.183	.005	.009	3	2
UCEC	JNK_pT183_Y185 →	-0.131	-1.986	.048	.010	3	2
UCEC	Lck →	+0.231	+2.000	.003	.010	3	2
UCEC	MSH6 →	-0.474	-2.105	<.001	.017	3	2
UCEC	mTOR_pS2448 →	-0.151	-2.095	.010	.017	3	2
UCEC	PDCD4 →	-0.367	-2.000	.047	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eIF4E by TCF3 expression — UCEC

Explore this box plot interactively →