TCF23

Across TCGA patient cohorts, TCF23 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TCF23-associated genes across cancer lineages are FoxM1, Smad3, and FOXO3a. Each is linked with TCF23 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF23-to-partner and partner-to-TCF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TCF23-low versus TCF23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF23→partner) and Y-score (partner→TCF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.362	+2.817	.022	.036	3	1
SKCM	Smad3 →	+0.183	+3.000	.046	.036	3	1
SKCM	FOXO3a →	-0.156	-3.000	.018	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FoxM1 by TCF23 expression — UCEC

Explore this box plot interactively →