TCF20

Across TCGA patient cohorts, TCF20 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF20-associated genes across cancer lineages are 4E-BP1, FoxM1, and ATM. Each is linked with TCF20 in more than 3 cancer types. Because this analysis shows association rather than direction, both TCF20-to-partner and partner-to-TCF20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TCF20-low versus TCF20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF20→partner) and Y-score (partner→TCF20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.223	+1.502	.002	<.001	3	4
UCEC	FoxM1 →	+0.161	+1.594	.019	.010	3	3
UCEC	ATM →	-0.482	-3.234	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.379	+1.341	.016	.017	3	3
BLCA	IRS1 →	+0.245	+2.820	.013	.035	3	2
LUAD	XRCC1 →	+0.144	+3.000	.033	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

4E-BP1 by TCF20 expression — UCEC

Explore this box plot interactively →