TCF20

Across TCGA cell cohorts, TCF20 mutation is significantly associated with the RNA expression of many other genes, with 706 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCF20-associated genes across cancer lineages are PPP1R3A, GAGE12F, and GNPNAT1. Each is linked with TCF20 in more than 2 cancer types. Because this analysis shows association rather than direction, both TCF20-to-partner and partner-to-TCF20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R3A grouped by TCF20-low versus TCF20-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF20→partner) and Y-score (partner→TCF20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPP1R3A →	+0.063	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	GAGE12F →	+1.263	+4.643	.002	.008	3	2
LARGE_INTESTINE	GNPNAT1 →	+0.556	+1.631	<.001	.004	3	2
LARGE_INTESTINE	CNIH1 →	+0.473	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	SMCHD1 →	+0.777	+2.459	.001	.003	3	2
LARGE_INTESTINE	MCM9 →	+0.564	+2.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 706 associations by consensus.

PPP1R3A by TCF20 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →