TCF19

Across TCGA patient cohorts, TCF19 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCF19-associated genes across cancer lineages are OR56A1, RNU6-686P, and MTATP6P29. Each is linked with TCF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF19-to-partner and partner-to-TCF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A1 grouped by TCF19-low versus TCF19-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF19→partner) and Y-score (partner→TCF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR56A1 →	+0.022	+4.282	.009	.009	3	2
SKCM	RNU6-686P →	+0.573	+3.661	<.001	.009	3	2
UCEC	MTATP6P29 →	+0.341	+3.396	<.001	.006	3	2
UCEC	RPL35AP →	+0.455	+2.763	<.001	.009	3	2
COAD	TRIM43 →	+0.053	+4.516	<.001	.009	3	2
UCEC	TRIM60 →	+0.074	+2.888	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

OR56A1 by TCF19 expression — SKCM

Explore this box plot interactively →