TCEANC

Across TCGA patient cohorts, TCEANC mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCEANC-associated genes across cancer lineages are VHL, 14-3-3_beta, and EGFR. Each is linked with TCEANC in more than 1 cancer types. Because this analysis shows association rather than direction, both TCEANC-to-partner and partner-to-TCEANC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by TCEANC-low versus TCEANC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCEANC→partner) and Y-score (partner→TCEANC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.885	-2.700	<.001	.006	3	2
UCEC	14-3-3_beta →	-0.101	-2.432	.010	.018	3	1
UCEC	EGFR →	-0.178	-2.000	.004	.010	3	1
UCEC	FoxM1 →	+0.231	+2.000	.022	.010	3	1
UCEC	ACC1 →	+0.307	+1.584	.031	.036	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.445	+1.884	.025	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

VHL by TCEANC expression — UCEC

Explore this box plot interactively →