TCEAL8

Across TCGA patient cohorts, TCEAL8 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCEAL8-associated genes across cancer lineages are EGFR_pY1068, p62 Lck ligand, and p90 RSK. Each is linked with TCEAL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCEAL8-to-partner and partner-to-TCEAL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TCEAL8-low versus TCEAL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCEAL8→partner) and Y-score (partner→TCEAL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.274	-2.459	.023	.020	3	1
UCEC	p62 Lck ligand →	+0.564	+3.584	<.001	.002	3	1
UCEC	p90 RSK →	+0.192	+2.817	.038	.036	3	1
UCEC	Rad50 →	-0.313	-2.459	.007	.020	3	1
UCEC	STAT3_pY705 →	-0.486	-2.459	<.001	.020	3	1
UCEC	MEK1 →	+0.549	+3.584	.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by TCEAL8 expression — UCEC

Explore this box plot interactively →