TCEAL4

Across TCGA patient cohorts, TCEAL4 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCEAL4-associated genes across cancer lineages are A-Raf_pS299, ERK2, and C-Raf. Each is linked with TCEAL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCEAL4-to-partner and partner-to-TCEAL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TCEAL4-low versus TCEAL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCEAL4→partner) and Y-score (partner→TCEAL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.164	-3.584	<.001	.002	3	2
UCEC	ERK2 →	+0.192	+2.000	.016	.030	3	2
UCEC	C-Raf →	+0.148	+3.584	.012	.002	3	2
UCEC	14-3-3_beta →	-0.083	-3.143	.044	.018	3	1
UCEC	eIF4G →	+0.342	+1.807	.007	.027	3	1
UCEC	GATA6 →	-0.152	-2.215	.020	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

A-Raf_pS299 by TCEAL4 expression — UCEC

Explore this box plot interactively →