TCAIM

Across TCGA patient cohorts, TCAIM mutation is significantly associated with the RNA expression of many other genes, with 1,723 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCAIM-associated genes across cancer lineages are RNA5SP86, MIR3616, and COPRS. Each is linked with TCAIM in more than 1 cancer types. Because this analysis shows association rather than direction, both TCAIM-to-partner and partner-to-TCAIM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP86 grouped by TCAIM-low versus TCAIM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCAIM→partner) and Y-score (partner→TCAIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP86 →	+0.418	+2.299	<.001	.004	3	2
LIHC	MIR3616 →	+0.284	+5.008	<.001	.004	3	2
UCEC	COPRS →	+0.380	+1.684	.004	.007	3	2
UCEC	GMPPB →	+0.403	+2.230	.004	.006	3	2
UCEC	TOP3A →	+0.511	+2.874	<.001	<.001	3	2
UCEC	NCAPH2 →	+0.508	+3.839	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,723 associations by consensus.

RNA5SP86 by TCAIM expression — UCEC

Explore this box plot interactively →