TCAIM

Across TCGA cell cohorts, TCAIM mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCAIM-associated genes across cancer lineages are GUCA2A, HCN4, and DRD3. Each is linked with TCAIM in more than 1 cancer types. Because this analysis shows association rather than direction, both TCAIM-to-partner and partner-to-TCAIM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by TCAIM-low versus TCAIM-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCAIM→partner) and Y-score (partner→TCAIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1
LARGE_INTESTINE	HCN4 →	+0.168	+3.415	.001	.009	3	1
LARGE_INTESTINE	DRD3 →	+0.011	+3.977	<.001	.001	3	1
LARGE_INTESTINE	FAM71A →	+0.060	+3.453	.001	.009	3	1
LARGE_INTESTINE	MAGEB1 →	+0.186	+3.878	<.001	.003	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GUCA2A by TCAIM expression — BLOOD_Leukemia

Explore this box plot interactively →