TCAF2

Across TCGA patient cohorts, TCAF2 mutation is significantly associated with the RNA expression of many other genes, with 1,197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TCAF2-associated genes across cancer lineages are IRAK1, RNU6-380P, and RNU2-47P. Each is linked with TCAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCAF2-to-partner and partner-to-TCAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRAK1 grouped by TCAF2-low versus TCAF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCAF2→partner) and Y-score (partner→TCAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRAK1 →	+0.627	+3.732	.008	<.001	3	2
UCEC	RNU6-380P →	+0.144	+3.885	<.001	.008	3	2
UCEC	RNU2-47P →	+0.106	+4.475	<.001	.003	3	2
UCEC	ACAP3 →	+0.539	+3.337	.004	.005	3	2
SKCM	PARP6 →	+0.756	+3.504	<.001	.002	3	2
UCEC	RNA5SP414 →	+0.429	+2.407	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,197 associations by consensus.

IRAK1 by TCAF2 expression — UCEC

Explore this box plot interactively →