Across TCGA pan-cancer cohorts, TCAF1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TCAF1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TCAF1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TCAF1 expression acts as an unfavorable survival marker.

COAD and LUSC are the cancer types where TCAF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.168	0.788	.005	12	view →
LUSC	OS	Median	II,III,IV	0.112	0.733	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TCAF1 tumor-vs-normal RNA expression · all TCAF1 data types