Across TCGA pan-cancer cohorts, TCAF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TCAF1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TCAF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TCAF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where TCAF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.409	0.869	.012	16	view →
LUAD	OS	Quartile	II,III,IV	0.437	0.913	.002	15	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	4	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	4	view →
PDAC	OS	Quartile	All	0.267	0.439	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TCAF1 tumor-vs-normal RNA expression · all TCAF1 data types