TC2N

Across TCGA patient cohorts, TC2N mutation is significantly associated with the RNA expression of many other genes, with 4,893 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TC2N-associated genes across cancer lineages are RN7SL712P, OLMALINC, and PRMT5-AS1. Each is linked with TC2N in more than 1 cancer types. Because this analysis shows association rather than direction, both TC2N-to-partner and partner-to-TC2N results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL712P grouped by TC2N-low versus TC2N-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TC2N→partner) and Y-score (partner→TC2N) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL712P →	+0.097	+5.008	<.001	.004	3	2
SKCM	OLMALINC →	+0.353	+1.784	.007	.007	3	2
UCEC	PRMT5-AS1 →	+0.180	+3.376	.002	.004	3	2
SKCM	RN7SL809P →	+0.322	+1.591	<.001	.003	3	2
UCEC	KCTD7 →	+0.574	+2.595	<.001	<.001	3	2
SKCM	MRPS31P4 →	+0.481	+2.334	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,893 associations by consensus.

RN7SL712P by TC2N expression — HNSC

Explore this box plot interactively →