TC2N

Across TCGA patient cohorts, TC2N mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TC2N-associated genes across cancer lineages are MEK1, ASNS, and EGFR. Each is linked with TC2N in more than 1 cancer types. Because this analysis shows association rather than direction, both TC2N-to-partner and partner-to-TC2N results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TC2N-low versus TC2N-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TC2N→partner) and Y-score (partner→TC2N) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.565	+3.169	<.001	<.001	3	2
UCEC	ASNS →	+0.445	+1.584	.001	.036	3	2
SKCM	EGFR →	-0.128	-1.678	.040	.022	3	2
UCEC	14-3-3_beta →	-0.109	-1.787	.005	.025	3	1
UCEC	eIF4G →	+0.275	+2.999	.023	.035	3	1
UCEC	Heregulin →	-0.142	-2.807	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MEK1 by TC2N expression — UCEC

Explore this box plot interactively →