TC2N

Across TCGA cell cohorts, TC2N mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TC2N-associated genes across cancer lineages are CETN1, FSHR, and SPATA31D4. Each is linked with TC2N in more than 1 cancer types. Because this analysis shows association rather than direction, both TC2N-to-partner and partner-to-TC2N results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CETN1 grouped by TC2N-low versus TC2N-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TC2N→partner) and Y-score (partner→TC2N) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CETN1 →	+0.008	+4.437	<.001	.004	3	2
BREAST	FSHR →	+0.043	+5.781	<.001	.001	3	1
BREAST	SPATA31D4 →	+0.016	+5.169	<.001	.005	3	1
LARGE_INTESTINE	TFDP3 →	+0.018	+4.196	.006	.002	3	1
SKIN	PAGE4 →	+0.800	+3.920	<.001	.005	3	1
SKIN	SLC5A7 →	+0.015	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CETN1 by TC2N expression — SKIN

Explore this box plot interactively →