TBXAS1

Across TCGA patient cohorts, TBXAS1 mutation is significantly associated with the RNA expression of many other genes, with 2,445 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBXAS1-associated genes across cancer lineages are EMC1, ALDH18A1, and XPNPEP1. Each is linked with TBXAS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBXAS1-to-partner and partner-to-TBXAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMC1 grouped by TBXAS1-low versus TBXAS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBXAS1→partner) and Y-score (partner→TBXAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EMC1 →	+0.452	+2.768	.007	<.001	3	3
UCEC	ALDH18A1 →	+0.425	+1.885	.002	.001	3	3
UCEC	XPNPEP1 →	+0.376	+2.332	.003	.003	3	3
LUAD	TEMN3-AS1 →	+0.432	+4.197	<.001	.009	3	3
UCEC	RASSF1-AS1 →	+0.451	+3.850	<.001	<.001	2	3
SKCM	ERCC2 →	+0.365	+2.709	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,445 associations by consensus.

EMC1 by TBXAS1 expression — SKCM

Explore this box plot interactively →