TBXAS1

Across TCGA patient cohorts, TBXAS1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBXAS1-associated genes across cancer lineages are CDK1, PCNA, and INPP4B. Each is linked with TBXAS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBXAS1-to-partner and partner-to-TBXAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by TBXAS1-low versus TBXAS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBXAS1→partner) and Y-score (partner→TBXAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDK1 →	+0.217	+2.321	.001	.032	3	3
COAD	PCNA →	+0.302	+2.820	.013	.035	3	3
SKCM	INPP4B →	-0.204	-3.584	.007	.002	3	2
UCEC	mTOR_pS2448 →	-0.177	-2.980	.001	<.001	3	2
UCEC	ASNS →	+0.428	+2.321	.001	.033	3	2
UCEC	ATM →	-0.629	-2.446	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

CDK1 by TBXAS1 expression — SKCM

Explore this box plot interactively →