TBX6

Across TCGA patient cohorts, TBX6 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,219 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBX6-associated proteins across cancer lineages are HIRIP3, DCTPP1, and RFTN1. Each is linked with TBX6 in more than 5 cancer types. Because this analysis shows association rather than direction, both TBX6-to-partner and partner-to-TBX6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBX6 versus HIRIP3 in BRCA, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX6→partner) and Y-score (partner→TBX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HIRIP3 →	+0.507	+0.755	<.001	<.001	3	6
BRCA	DCTPP1 →	+0.527	+0.606	<.001	<.001	3	5
LSCC	RFTN1 →	-0.413	-0.537	<.001	<.001	3	4
LSCC	CTNND1 →	+0.259	+0.727	<.001	<.001	3	4
LUAD	ZFYVE19 →	+0.228	+0.287	<.001	.001	3	4
LUAD	SLC43A2 →	-0.482	-0.431	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,219 associations by consensus.

TBX6 vs HIRIP3 — BRCA

Explore this scatter interactively →