TBX6

Across TCGA patient cohorts, TBX6 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX6-associated genes across cancer lineages are eIF4G, ERK2, and GAPDH. Each is linked with TBX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX6-to-partner and partner-to-TBX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by TBX6-low versus TBX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX6→partner) and Y-score (partner→TBX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.303	+2.999	.021	.035	3	1
UCEC	ERK2 →	+0.175	+3.169	.032	.018	3	1
UCEC	GAPDH →	+0.457	+3.169	.045	.018	3	1
UCEC	HSP70 →	-0.342	-2.990	.044	.036	3	1
UCEC	MEK1 →	+0.388	+3.321	.012	.010	3	1
UCEC	MSH6 →	-0.511	-2.321	<.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4G by TBX6 expression — UCEC

Explore this box plot interactively →