TBX6

Across TCGA cell cohorts, TBX6 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBX6-associated genes across cancer lineages are PTH, FBXO40, and IZUMO3. Each is linked with TBX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX6-to-partner and partner-to-TBX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by TBX6-low versus TBX6-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX6→partner) and Y-score (partner→TBX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PTH →	+0.083	+5.977	<.001	.001	3	2
LUNG_NSCLC_LUAD	FBXO40 →	+0.012	+5.189	<.001	<.001	3	2
LUNG_NSCLC_LUAD	IZUMO3 →	+0.032	+4.947	<.001	.001	3	2
LARGE_INTESTINE	ADH1A →	+0.112	+3.505	<.001	<.001	3	2
SOFT_TISSUE	OR13C3 →	+0.056	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR14J1 →	+0.006	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PTH by TBX6 expression — SOFT_TISSUE

Explore this box plot interactively →