TBX5-AS1

Across TCGA pan-cancer cohorts, TBX5-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TBX5-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TBX5-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TBX5-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

ACC, LUSC, and CESC are the cancer types where TBX5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.274	0.718	<.001	85	view →
LUSC	OS	Tertile	All	0.301	0.464	.003	51	view →
CESC	DFS	Quartile	III,IV	0.464	0.782	.002	44	view →
LIHC	DFS	Tertile	All	0.391	0.593	<.001	41	view →
SKCM	DFS	Quartile	II,III,IV	0.730	0.463	.007	40	view →
LUAD	OS	Quartile	II,III,IV	0.746	0.413	<.001	38	view →
UCEC	OS	Tertile	All	0.874	0.936	.005	36	view →
KIRC	DFS	Tertile	IV	0.298	0.609	.008	27	view →
UVM	DFS	Median	All	0.407	0.722	.007	24	view →
GBM	OS	Quartile	All	0.297	0.599	.011	14	view →
HNSC	OS	Median	All	0.635	0.769	.014	13	view →
PRAD	DFS	Tertile	All	0.939	0.852	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TBX5-AS1–ACC (OS)

Open the ACC breakdown →