TBX3

Across TCGA patient cohorts, TBX3 mutation is significantly associated with the RNA expression of many other genes, with 3,806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX3-associated genes across cancer lineages are RN7SKP46, CDRT15P7, and RNU6-48P. Each is linked with TBX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBX3-to-partner and partner-to-TBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP46 grouped by TBX3-low versus TBX3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX3→partner) and Y-score (partner→TBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP46 →	+0.170	+5.570	<.001	<.001	3	4
CESC	CDRT15P7 →	+0.078	+5.669	<.001	.003	3	3
BRCA	RNU6-48P →	+0.528	+2.958	.002	.003	3	3
COAD	VN1R36P →	+0.155	+4.409	<.001	.004	3	3
LUSC	GRPEL2P2 →	+0.088	+2.794	<.001	.001	3	3
UCEC	RRP9 →	+0.316	+2.592	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,806 associations by consensus.

RN7SKP46 by TBX3 expression — BLCA

Explore this box plot interactively →