TBX3

Across TCGA patient cohorts, TBX3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX3-associated genes across cancer lineages are 4E-BP1_pT70, 4E-BP1, and JNK2. Each is linked with TBX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX3-to-partner and partner-to-TBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by TBX3-low versus TBX3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX3→partner) and Y-score (partner→TBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1_pT70 →	+0.324	+2.824	.003	.036	3	3
UCEC	4E-BP1 →	+0.318	+3.700	<.001	.001	3	3
UCEC	JNK2 →	+0.238	+3.727	<.001	<.001	3	3
UCEC	C-Raf →	+0.167	+1.353	<.001	.015	3	3
UCEC	14-3-3_beta →	-0.096	-2.880	.002	.001	3	2
UCEC	eIF4E →	+0.144	+2.713	.029	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1_pT70 by TBX3 expression — LUAD

Explore this box plot interactively →