TBX3

Across TCGA cell cohorts, TBX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,458 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TBX3-associated GO terms across cancer lineages are Sinoatrial node cell differentiation, Sinoatrial node cell development, and Cardiac jelly development. Each is linked with TBX3 in more than 16 cancer types. Because this analysis shows association rather than direction, both TBX3-to-partner and partner-to-TBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sinoatrial node cell differentiation grouped by TBX3-low versus TBX3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX3→partner) and Y-score (partner→TBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Sinoatrial node cell differentiation →	+1.826	+4.052	<.001	<.001	3	17
URINARY_TRACT	Sinoatrial node cell development →	+1.460	+3.116	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Cardiac jelly development →	+1.457	+3.334	<.001	<.001	3	15
LUNG_SCLC	Atrioventricular canal morphogenesis →	+1.186	+3.330	<.001	<.001	3	11
BONE	Sinoatrial node development →	+1.157	+2.605	.001	.005	3	11
BREAST	Cardiac pacemaker cell differentiation →	+0.168	+2.270	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,458 associations by consensus.

Sinoatrial node cell differentiation by TBX3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →