TBX20

Across TCGA patient cohorts, TBX20 mutation is significantly associated with the RNA expression of many other genes, with 1,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX20-associated genes across cancer lineages are C1orf226, PDP2, and RNU6-1067P. Each is linked with TBX20 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX20-to-partner and partner-to-TBX20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf226 grouped by TBX20-low versus TBX20-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX20→partner) and Y-score (partner→TBX20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	C1orf226 →	+0.950	+2.713	<.001	.003	3	3
SKCM	PDP2 →	+0.477	+3.497	.004	.002	3	3
CESC	RNU6-1067P →	+0.456	+4.569	<.001	.005	3	3
UCEC	LIN54 →	+0.475	+2.010	.004	.006	3	3
UCEC	MPV17L2 →	+0.382	+3.595	.005	.001	3	3
UCEC	MLX →	+0.501	+2.955	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,576 associations by consensus.

C1orf226 by TBX20 expression — SKCM

Explore this box plot interactively →