TBX20

Across TCGA patient cohorts, TBX20 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX20-associated genes across cancer lineages are Notch1, Cyclin-B1, and Myosin-IIa_pS1943. Each is linked with TBX20 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX20-to-partner and partner-to-TBX20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TBX20-low versus TBX20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX20→partner) and Y-score (partner→TBX20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.184	+2.331	.002	.019	3	2
UCEC	Cyclin-B1 →	+0.514	+2.115	.036	.019	3	2
LUAD	Myosin-IIa_pS1943 →	+0.492	+3.000	.031	.035	3	1
LUAD	PTEN →	+0.260	+3.000	.049	.035	3	1
SKCM	Rb_pS807_S811 →	+0.485	+2.584	.015	.011	3	1
SKCM	Caveolin-1 →	+0.785	+3.169	.006	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by TBX20 expression — UCEC

Explore this box plot interactively →