TBX20

Across TCGA cell cohorts, TBX20 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBX20-associated genes across cancer lineages are C4orf51, ZC2HC1B, and IFNA21. Each is linked with TBX20 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX20-to-partner and partner-to-TBX20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf51 grouped by TBX20-low versus TBX20-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX20→partner) and Y-score (partner→TBX20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C4orf51 →	+0.446	+4.643	.001	.008	3	1
CNS	ZC2HC1B →	+0.034	+4.169	<.001	.008	3	1
CNS	IFNA21 →	+0.026	+4.832	<.001	.002	3	1
CNS	TBXT →	+0.742	+4.832	<.001	.002	3	1
CNS	OR13H1 →	+0.032	+4.472	.002	.004	3	1
CNS	SPRR2F →	+0.060	+4.169	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

C4orf51 by TBX20 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →