TBX2

Across TCGA patient cohorts, TBX2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX2-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Cyclin-B1. Each is linked with TBX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBX2-to-partner and partner-to-TBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TBX2-low versus TBX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX2→partner) and Y-score (partner→TBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.922	+2.522	<.001	<.001	3	4
UCEC	ATM →	-0.381	-1.662	.017	.011	3	3
UCEC	Cyclin-B1 →	+0.752	+3.807	<.001	<.001	3	3
UCEC	STAT3_pY705 →	-0.271	-1.362	.003	.037	3	2
UCEC	4E-BP1 →	+0.309	+2.730	.001	.003	3	2
UCEC	eIF4G →	+0.243	+1.807	.026	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by TBX2 expression — UCEC

Explore this box plot interactively →