TBX2

Across TCGA cell cohorts, TBX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,902 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TBX2-associated GO terms across cancer lineages are Regulation of transcription initiation by RNA polymerase II, Calcium-independent cell-matrix adhesion, and Sodium ion export across plasma membrane. Each is linked with TBX2 in more than 7 cancer types. Because this analysis shows association rather than direction, both TBX2-to-partner and partner-to-TBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription initiation by RNA polymerase II grouped by TBX2-low versus TBX2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX2→partner) and Y-score (partner→TBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of transcription initiation by RNA polymerase II →	+0.075	+0.686	.001	.002	3	8
SOFT_TISSUE	Calcium-independent cell-matrix adhesion →	+0.133	+2.538	<.001	<.001	3	8
OVARY	Sodium ion export across plasma membrane →	-0.172	-1.221	.001	.008	3	8
PANCREAS	Positive regulation of sodium ion transport →	-0.209	-0.826	.001	.002	3	7
SKIN	Cell communication involved in cardiac conduction →	-0.175	-2.852	<.001	<.001	3	7
SKIN	Negative regulation of transcription by RNA polymerase III →	+0.134	+2.329	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,902 associations by consensus.

Regulation of transcription initiation by RNA polymerase II by TBX2 expression — PANCREAS

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