TBX2

Across TCGA cell cohorts, TBX2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TBX2-associated genes across cancer lineages are RXFP3, ASB17, and CFAP97D2. Each is linked with TBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX2-to-partner and partner-to-TBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RXFP3 grouped by TBX2-low versus TBX2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX2→partner) and Y-score (partner→TBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RXFP3 →	+0.068	+4.169	<.001	.008	3	2
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	2
LUNG_NSCLC_LUSC	CFAP97D2 →	+0.020	+4.643	<.001	.008	3	1
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
SOFT_TISSUE	CT45A9 →	+1.000	+4.635	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

RXFP3 by TBX2 expression — CNS

Explore this box plot interactively →