TBX18

Across TCGA patient cohorts, TBX18 mutation is significantly associated with the RNA expression of many other genes, with 4,534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX18-associated genes across cancer lineages are PBK, RPL23AP82, and HAUS1. Each is linked with TBX18 in more than 4 cancer types. Because this analysis shows association rather than direction, both TBX18-to-partner and partner-to-TBX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by TBX18-low versus TBX18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX18→partner) and Y-score (partner→TBX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.939	+2.546	<.001	<.001	3	5
COAD	RPL23AP82 →	+0.492	+3.459	<.001	.005	3	4
UCEC	HAUS1 →	+0.535	+2.254	<.001	<.001	3	4
UCEC	SEC13 →	+0.416	+2.906	<.001	<.001	3	4
UCEC	FANCC →	+0.443	+1.947	<.001	<.001	3	4
UCEC	GLOD4 →	+0.540	+2.917	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,534 associations by consensus.

PBK by TBX18 expression — UCEC

Explore this box plot interactively →