TBX18

Across TCGA cell cohorts, TBX18 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBX18-associated genes across cancer lineages are OTC, CENPVL3, and AGRP. Each is linked with TBX18 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX18-to-partner and partner-to-TBX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTC grouped by TBX18-low versus TBX18-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX18→partner) and Y-score (partner→TBX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OTC →	+0.040	+2.705	.001	.006	3	2
OESOPHAGUS	CENPVL3 →	+0.703	+4.906	<.001	.006	3	1
SKIN	AGRP →	+0.132	+2.556	.001	.006	3	1
SKIN	PPP3R2 →	+0.012	+3.935	<.001	<.001	3	1
LUNG_SCLC	TSPAN16 →	+0.032	+3.256	.006	.005	3	1
LUNG_SCLC	OR51B6 →	+0.136	+3.256	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OTC by TBX18 expression — SKIN

Explore this box plot interactively →