TBX10

Across TCGA patient cohorts, TBX10 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX10-associated genes across cancer lineages are HSP70, Rictor_pT1135, and STAT5a. Each is linked with TBX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX10-to-partner and partner-to-TBX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by TBX10-low versus TBX10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX10→partner) and Y-score (partner→TBX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSP70 →	-0.419	-2.000	.020	.032	3	1
UCEC	Rictor_pT1135 →	-0.128	-2.000	.005	.032	3	1
UCEC	STAT5a →	+0.387	+3.169	.032	.018	3	1
UCEC	VHL →	-1.117	-3.584	<.001	.002	3	1
UCEC	Axl →	+0.185	+2.818	.047	.035	2	1
UCEC	JNK2 →	+0.271	+2.700	.002	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HSP70 by TBX10 expression — UCEC

Explore this box plot interactively →