TBX10

Across TCGA cell cohorts, TBX10 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBX10-associated genes across cancer lineages are PRM2, GPR101, and GAGE10. Each is linked with TBX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX10-to-partner and partner-to-TBX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM2 grouped by TBX10-low versus TBX10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX10→partner) and Y-score (partner→TBX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRM2 →	+0.020	+4.384	<.001	.006	3	1
BLOOD_Leukemia	GPR101 →	+0.102	+3.551	<.001	.009	3	1
BLOOD_Leukemia	GAGE10 →	+0.128	+4.450	<.001	.001	3	1
BLOOD_Leukemia	TLE7 →	+0.025	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PRM2 by TBX10 expression — BLOOD_Leukemia

Explore this box plot interactively →