Across TCGA patient cohorts, TBX1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,454 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBX1-associated proteins across cancer lineages are PALM, MVP, and PARP4. Each is linked with TBX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBX1-to-partner and partner-to-TBX1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX1→partner) and Y-score (partner→TBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PALM →	+0.479	+0.795	.004	.003	3	4
LUAD	MVP →	-0.472	-0.820	<.001	<.001	3	4
GBM	PARP4 →	-0.417	-0.412	<.001	.007	3	4
LSCC	AGFG2 →	-0.395	-0.805	<.001	<.001	3	4
OV	GALE →	-0.382	-0.634	.005	.004	3	4
LSCC	MAP1LC3A →	+0.761	+0.771	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,454 associations by consensus.

Exploration

TBX1 survival (RNA) · tumor vs normal (RNA) · all TBX1 data types