Across TCGA patient cohorts, TBX1 protein abundance is significantly associated with the RNA expression of many other genes, with 753 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBX1-associated genes across cancer lineages are TRAJ53, IGKV1D-17, and NKAIN4. Each is linked with TBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX1-to-partner and partner-to-TBX1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX1→partner) and Y-score (partner→TBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAJ53 →	+1.712	+0.817	<.001	.004	3	2
LUAD	IGKV1D-17 →	-1.910	-0.634	.001	<.001	3	2
LUAD	NKAIN4 →	-0.291	-0.634	.004	<.001	3	1
LUAD	ACD →	-1.063	-0.619	<.001	.001	3	1
LUAD	TOX3 →	-1.552	-0.619	.003	.001	3	1
LUAD	TMEM109 →	-0.565	-0.634	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 753 associations by consensus.

Exploration

TBX1 survival (RNA) · tumor vs normal (RNA) · all TBX1 data types